Antifungal Ketoconazole Shampoo Additive CAS No. 65277-42-1

• CAS No.: 65277-42-1
• Grade: Cosmetics Grade
• Function: Antifungal
• Certification: MSDS
• Usage: Cosmetic Raw Materials, Hair Care Chemicals, Detergent Raw Materials, Oral Care Chemicals
• Raw Material: Cosmetics Grade
• Transport Machine: Ordinary Goods Truck
• Transport Package: Drum
• Specification: 25kg/drum
• Origin: China
• HS Code: 2933290090

Product Description

Ketoconazole is a synthetic antifungal drug. It can highly selectively interfere with the activity of fungal cytochrome P-450, thereby inhibiting the biosynthesis of ergosterol on the fungal cell membrane, damaging the fungal cell membrane and changing its permeability, allowing important intracellular substances to leak out, thereby achieving resistance Fungal action.

Product name:Ketoconazole Antifungal Shampoo additive CAS No.65277-42-1

Characteristics:
CAS No.65277-42-1
Appearance:Powder
Package:25kg/drum
Usage:Shampoo,medicine
HS Code:2933290090

Description:
This product belongs to the pyrrole antifungal drug. It has antibacterial effect on deep infection fungi such as Candida, Color fungus, Coccidioides, Histoplasma, Sporothrix, etc. It also has antibacterial effect on Trichophyton, etc. Antibacterial activity. This product has poor effect on Aspergillus, Sporothrix Schenkerii, certain spore families, and Mucor. By interfering with the activity of cytochrome P-450, this product inhibits the biosynthesis of ergosterol, the main sterol in the fungal cell membrane, damages the fungal cell membrane and changes its permeability, so that important intracellular materials leak out. This product can inhibit the biosynthesis of fungal triacylglycerol and phospholipid, inhibit the activity of oxidase and peroxidase, and cause the accumulation of hydrogen peroxide in the cell, which leads to cell submicron structure degeneration and cell necrosis. Candida albicans can inhibit the process of its transformation from spores to invasive hyphae.

Packing:25kg/drum

Application:
Shampoo,medicine

Specification:

TESTS	SPECIFICATION
Description	A white to almost white powder
Solubility	Practically insoluble in water, freely soluble in methylene chloride, soluble in methanol, sparingly soluble in Ethanol (96%).
Melting point	Between 1480C to 1520C.
Infrared absorption	Infrared absorption spectrum of sample should be concordant with that of working standard spectrum.
Specific Rotation	Between -1.00 and +1.00 (T= 200C)
Heavy Metals	NMT 0.002%
Loss on drying	NMT 0.5%w/w
Residue on ignition	NMT 0.1%w/w
Related substances by TLC	The principal spot obtained from the test solution has about the same size and Rf value as that obtained from the standard solution and the sum of the intensities of any secondary spots obtained from the test solution does not exceed the intensity of the principal spot obtained from the diluted standard solution. (NMT: 0.5%)
Assay by titrimetry (on dried basis)	NLT 98.0% w/w & NMT 102.0%w/w
Residual Solvents Methanol Acetone Ethyl Acetate	NMT 3000 ppm MNT 5000 ppm NMT 5000 ppm
Bulk Density
Untapped Density	For your information
Tapped Density	For your information